Staff


Great Ormond Street Hospital Laboratory Medicine provides a service which is led and supported by a range of clinical and technical experts. Please scroll down to find out about our clinical and technical leads or click on one of the links below to navigate directly to a department of interest.

 

Management Team                   
Chemical Pathology
Genetics
Haematology                                
Histopathology
Immunology                                 
Microbiology, Virology and Infection Control
Paediatric Malignancy Unit

 


Management Team


 

Dr Marian Malone
Specialty Lead

Marian MaloneDr Marian Malone attended Medical School at University College in Dublin, Ireland where she graduated in 1977 with a medical degree, MB, BCh, BAO (Hons).  Her training in general histopathology was undertaken at the London Hospital from 1978 to 1980 and at Kings College Hospital London from 1983 to 1986. Her paediatric pathology training was obtained at GOSH between 1983 and 1986.  She returned to GOSH as Consultant Paediatric Pathologist/Honorary Senior Lecturer at the UCL Institute of Child Health (ICH) in 1986 where she has worked ever since.

Dr Malone obtained Membership of the Royal College of Pathologists in 1985 and Fellowship in 1997. Since 1999 she has been Director of Laboratories at GOSH.  She has been co-author on over 80 original papers, reviews and book chapters in the medical literature, and has been an Associate Editor of the international medical journal Paediatric and Developmental Pathology since 2000.  She is co-author of a textbook of paediatric surgical pathology.  She was the Chief Examiner in Paediatric Pathology at the Royal College of Pathologists from 2004-2009, since which she has taken the lead for developing the paediatric pathology curriculum and training programme at the College.  She has been a resident tutor on four advanced courses on paediatric pathology held annually by the International Paediatric Pathology Association.  She has been a member of the committee of the Pediatric Pathology Society with responsibility for publications since 2000.  She has had an interest in histiocytic disorders for many years and has been the national reviewing pathologist for Langerhans Cell Histiocytosis (LCH)  for the UK Children's Cancer and Lymphoma Group for ten years. She has had an interest in sudden unexpected death in infancy (SUDI) for many years  and has co-authored many scientific publications on the subject. She has had a long association with the Foundation for the Study of Infant Death (FSID).

Within the past year Dr Malone has been appointed NHS London Clinical Lead for Paediatric Pathology and is a member of the London Clinical Senate. She chairs the Modernising Pathology Paediatric Pathology Clinical Expert Panel for London  and is a member of the Modernising Pathology Programme Board for London. 


 

David Wells
Lead Laboratory Manager: Chemical Pathology, Histopathology, Microbiology, Virology and Infection Control

David WellsDavid Wells is the Lead Laboratory Manager and Lead Biomedical Scientist, with operational responsibility for Chemical Pathology (including Newborn Screening, Special Enzyme Laboratory, Metabolic Laboratory and Special Routine Chemistry), Microbiology and Histopathology. David also has responsibility for Health and Safety and external business development for Laboratory Medicine.
Having undertaken his training at Cambridge University Hospitals NHS Trust, David is now a Fellow of the Institute of Biomedical Science (IBMS) and a Chartered Scientist. He is a member of the IBMS Special Advisory Group for Clinical Chemistry. He has a diverse experience of providing pathology services to primary, secondary and tertiary care. David has a research interest in Elemental Analysis.

 

Christine Morris
Laboratory Manager: Haematology, Paediatric Malignacy Unit, Immunology 

Christine MorrisChristine is the Senior Laboratory Manager with operational responsibility for Blood Sciences, Blood Transfusion, Immunology, Cell Therapy and the Haematology Cellular and Molecular Diagnostic Service (HCMDS).  Christine also serves as the Lead in Quality and Training for Laboratory Medicine. She has many years experience working in NHS pathology laboratories, commencing her career at the Regional Blood Transfusion Centre in Newcastle Upon Tyne then notably spening 25 years at the Royal London Hospital where she managed the automated Haematology Laboratory with additional responsibilities and special interest in Training and Point of Care Testing. 

Christine joined GOSH in 2007 as the Haematology Laboratory Manager. Christine holds a MSc in Haematology and is a Fellow and Chartered Scientist of theInstituteofBiomedical Science.

 

Nick Lench
Director, North East Thames Regional Genetics Service

 

Nick LenchNick Lench is the Director of the NE Thames Regional Genetics Service at GOSH. Since his appointment in 2009, the laboratories have developed an active translational R&D programme aimed at the development and implementation of new technologies for patient benefit including non-invasive prenatal diagnosis, chromosomal microarrays and next generation DNA sequencing. Nick has extensive experience in academic research and bio-industry, was appointed Professor of Medical Genetics at Cardiff University and is author of over 100 peer reviewed publications. He has extensive experience of Intellectual Property management, technology transfer, licensing and commercialisation of genetics technologies and has held senior management positions as Director of the Wales Genetics Knowledge Park, Programme Director at Oxagen Ltd and founding CEO of London Genetics Ltd.

 


Clinical and Technical Leads


 

Chemical Pathology

Professor Simon Heales
Clincal Lead

Simon HealesSimon Heales is Head of Chemical Pathology/Director of Newborn Screening at Great Ormond Street Hospital and UCL (Institute of Child Health) Professor of Clinical Chemistry.  He directs a number of basic and translational research programmes that underpin the highly specialized diagnostic services within Chemical Pathology.  These projects include; (a) Biomarker discovery for diagnostic and disease monitoring of inherited disorders affecting mitochondrial, lysosomal and neurotransmitter metabolism, (b) Establishment of dried blood spot multiplexed enzyme assays for diagnosing patients with lysosomal disorders. (c) Central folate metabolism in mitochondrial disorders, (d) Biochemical mechanisms responsible for the ketogenic diet and (e) Lysosomal dysfunction and neurodegeneration.  To date he has published over 160 papers.  He also holds an appointment (Consultant Clinical Scientist) at the National Hospital (UCLH Foundation Trust) where he works with colleagues in the Neurometabolic Unit on the diagnosis of Mitochondrial and Neurotransmitter Disorders.

 

Helen Aitkenhead
Principal Clinical Scientist

Helen AitkenheadHelen Aitkenhead is a graduate of Aston University, Birmingham and University of Surrey, Guildford. Helen undertook her clinical scientist training at Charing Cross, St Mary's and Northwick Park Hospitals. Before coming to Great Ormond Street Hospital for Children, Helen worked as a Senior Clinical Scientist at Ealing Hospital.
Helen has interests in all aspects of paediatric clinical biochemistry as well as point of care testing, quality management and clinical scientist training.

Helen was appointed as Principal Clinical Scientist at GOSH in 2004 and Deputy Head of Chemical Pathology in 2011.

 



Genetics

 

Jonathan Waters
Head of Service (Cytogenetics)

 

Jonathan WatersDr Jonathan Waters is Head of Cytogenetics/Deputy Director within the Regional Genetics Service Laboratories and has an honorary Lectureship in Clinical and Molecular Genetics at ICH/UCL. Jonathan has degrees from Nottingham, where he also worked at the City Hospital and Glasgow. He has worked as a clinical scientist in Manchester, Cambridge and Birmingham together with several short stints in Switzerland. He was a Visiting Scientist at the MRC LMB (Laboratory for Molecular Biology) during his time in Cambridge and was NEQAS (EQA) Organiser in Clinical Cytogenetics while in Birmingham. He moved to Great Ormond St Hospital for Children in 2001. He is a Fellow of the Royal College of Pathologists and currently chairs the SAC (Specialist Advisory Committee) on Genetics and Clinical Embryology.  He has published around 35 papers and book chapters and maintains an interest in placental biology/prenatal diagnosis and the genetics of neurocognitive disorders. His principal focus is on managing and developing a modern cytogenetics (chromosome copy number) service with the emphasis on the introduction into diagnostic service of new molecular methods.


Lucy Jenkins
Head of Service (Molecular Genetics)

 

Lucy JenkinsLucy is the Head of Service for Molecular Genetics that, along with Cytogenetics forms the North East Thames Regional Genetics Laboratories. After graduating in Molecular Biology from Liverpool University Lucy undertook clinical scientist training and registration in the Yorkshire Regional DNA Laboratory, Leeds.  After 8 years she moved to Great Ormond Street Hospital to take up the post of Deputy Head in Molecular Genetics, obtaining Fellowship of the Royal College of Pathologists in 2006. Lucy then became Head of Service for Regional Molecular Genetics in 2009. Key interests include the genetics of hearing loss, surfactant protein deficiencies and non-invasive prenatal diagnosis.



Haematology

Dr Ri Liesner
Clinical Lead

 


Histopathology 

Dr Michael Ashworth
Clinical Lead

Michael AshworthMichael Ashworth is the Clinical Lead for Histopathology.  He completed his medical education at University College Dublin in 1980 and gained MRCPath in Liverpool in 1989.  Michael took up his first consultant post in 1993 at Bristol Childrens Hospital before taking up the position of Consultant Paediatric Pathologist at Alder Hey Childrens Hospital in 2001.  He joined GOSH in 2005.

Michael was Secretary of the British Paediatric Pathology Association between 2004 and 2009 and Secretary UK Cardiac Pathology Network  2010. He was a Council Member of the Paediatric Pathology Society  between 1999 and 2003 and Chair of the Standing Advisory Committee on Paediatric and Perinatal Pathology of the Royal College of Pathologists, UK from 2007 to 2011. He is also an examiner in paediatric pathology for the Royal College of Pathologists.

Michael's main areas of  interest include heart disease in children, pulmonary  disease and paediatric gastrointestinal disease producing publications in all these areas.  Michael also holds a diploma in the History of  Medicine of the Society of Apothecaries.

 

Dr Tom Jacques
Consultant Neuropathologist

Tom JacquesDr Tom Jacques runs a research group at the UCL Institute of Child Health focussing on brain tumours and paediatric epilepsy and provides the diagnostic neuropathology service for GOSH. He has held a Clinician Scientist Award for the past 6 years and have recently been awarded a nationally competitive HEFCE Clinical Senior Lectureship. Tom's research focuses on the role of stem cells in the development of paediatric brain disease. Specifically, he have recently shown that the major types of brain tumour can arise from stem cells and that the type of tumour is determined by the initiating genetic mutation (Jacqueset al.EMBO J 2010;29:222-35). Tom has also isolated a pathological stem cell from a malformation of cortical development in children with severe epilepsy (Yasinet al.Acta Neuropathologica 2010;120:85-96).

 

Professor Neil Sebire

Neil SebireProfessor Neil Sebire is Professor of Paediatric and Developmental Pathology at ICH/UCL and Consultant Paediatric Pathologist at GOSH. Having initially trained in Obstetrics and Fetal Medicine, he trained in diagnostic pathology and now has research interests in placental pathology, paediatric tumour diagnosis and investigation of infant deaths.

 

 

 

 

 

 

Dr Liina Kiho
Consultant Pathologist

LiinaLiina Kiho completed her medical education at Tartu University, Estonia, in 1992 with a medical degree equivalent to MB BS (Hons) and undertook her training in general Histopathology at Tartu University Clinics and North-Estonian Regional Hospital, Tallinn, between 1992 and 1996. Liina gained her paediatric and perinatal training through apprenticeships at several hospitals in different countries, including Germany, Sweden and the Unites States. She was a pioneer in paediatric pathology in Estonia, by promoting it as a separate subspecialty of pathology and by setting up a network of paediatric and perinatal pathology at the main teaching hospitals of the country.

In 2004 Liina moved to the UK where she took up a post of a full time Consultant Paediatric and Perinatal Pathologist at Barts and The London NHS Trust and worked there until 2011. In January 2012 she took up the position of Consultant Paediatric Pathologist at Great Ormond Street Hospital. In 2010 she gained FRCPath by nomination. She is a member of BRIPPA and a member of the committee of the Pediatric Pathology Society.

Liina has a wide experience in perinatal and paediatric autopsy pathology, including specialist autopsy work for HM Coroners and for the Metropolitan Police. She is the Clinical Lead for the Mortuary Service at GOSH. Her main area of interest is sudden unexpected infant death (SUDI) and related issues.

 

Glenn Anderson
Clinical Electron Microscopist

Glenn AndersonGlenn Anderson provides an ultrastructural diagnostic service to GOSH and other institutions in the UK and abroad. Electron microscopy is of value in the diagnosis of renal, neuromuscular and lysosomal storage disorders as well as other rare paediatric diseases. Glenn also has a particular interest in metabolic disorders including the neuronal ceroid lipofuscinoses and leads one of the few units in Europe to provide a prenatal diagnostic service for these conditions.

Glenn actively collaborates with clinical and scientific colleagues in research projects on a variety of topics, where ultrastructural morphology may aid understanding of disease processes and etiology.

 

 


Immunology

 

Dr Cathy Cale
Clinical Lead

Cathy CaleCatherine Cale is dually trained in Paediatric Immunology and Immunopathology and has been a consultant at GOSH since 2001.  In her current role she is Clinical Lead for the Immunology laboratory (which provides a nationally funded and recognised service for primary immune deficiency)  and is one of the Consultants who run the inpatient and outpatient clinical services for children with primary immune deficiencies.  In the laboratory service her interests lie in developing novel and robust diagnostic tests for patients with immune deficiency and other immunological disorders. Cathy is currently interim Co-Medical Director at GOSH.  

 

 


Microbiology, Virology and Infection Control

Dr Garth Dixon
Clinical Lead

Garth Dixon
Garth Dixon is expert Paediatric Microbiologist and currently Lead Clinician for the Department of Microbiology, Virology and Infection Prevention and Control.  He has been a consultant at GOHS for five years.

Garth Dixon trained in paediatrics for six years and worked as a general paediatric registrar until undergoing training in Microbiology at the Royal Free Hospital then GOSH.  He obtained MRCPath in 2006 and took up a consultant post that year. Garth Dixon was awarded his PhD in 2000 at ICH

Garth has a special interest in using the latest molecular techniques, including whole genome sequencing, to better define how certain bacteria are able to cause more severe disease than others. Garth maintains a research interests in pathogenesis of Meningococcal disease, specifically, designing novel vaccines to help prevent the disease and also investigating how the bacterium induces damage to the blood vessel walls in severe forms of the disease.

 

Dr John Hartley
Consultant Microbiologist

John Hartley

 

Dr James Soothill
Consultant Microbiologist

James SoothillJames Soothill has been a consultant Microbiologist at GOSH for over ten years. He is responsible for the development of antibiotic policy and surveillance of infections of central venous catheters. His interests include the prevention of central venous catheter infection as well as the development for novel methods for the detection and control of  infection by antibiotic resistant bacteria.

 

 

 

 

 

 


Paediatric Malignancy Unit

Dr Helena Kempski
Clinical Lead

Dr Helena Kempski formally transferred to Great Ormond Street Hospital in 2004, from the Institute of Child Health (ICH) to head the Paediatric Malignancy Unit (PMU). She previously held the academic post of Senior Research Fellow in the Molecular Haematology and Cancer Biology (MHCB) unit at ICH and continues to maintain an honorary research position with UCL/ICH.  Helena's research interests include: (1) Acquired genomic changes in the acute leukaemias of infancy and childhood, (2) Transient abnormal myelopoiesis in Down Syndrome newborns, and (3) The application of single cell analysis in minimal residual disease. In addition to directing the PMU hospital diagnostic service, Helena is a member of the steering group committee of the UK Cancer Cytogenetics Group (UKCCG), and is a group leader in the MHCB research unit at UCL/ICH.

 

© 2011 Great Ormond Street Hospital for Children NHS Trust