Aminoglycoside induced deafness


The homoplasmic mutation m.1555A>G in the mitochondrial MT-RNR1 (12S rRNA) gene has been associated with aminoglycoside-induced and nonsyndromic sensorineural deafness. Testing is offered to patients likely to receive aminoglycosides and also to individuals with hearing loss, particularly where maternal inheritance has been noted.

Also known as

mitochondrial deafness

Request a test

When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test.

Additional information

For additional information please click on the link

Sending address

Rare & Inherited Disease Laboratory
London North Genomic Laboratory Hub
Great Ormond Street Hospital for Children
Levels 4-6 Barclay House
37 Queen Square

Laboratory service


Sample requirements

Blood sample in EDTA

Reference range

Not applicable

Turnaround time

10 days

Disease / group



Upon request

Call in advance?

Not required


The Genetics Laboratories provide an extensive range of Cytogenetics and Molecular Genetics diagnostic testing services.

© 2011 Great Ormond Street Hospital for Children NHS Trust