Aminoglycoside induced deafness


Description

The homoplasmic mutation m.1555A>G in the mitochondrial MT-RNR1 (12S rRNA) gene has been associated with aminoglycoside-induced and nonsyndromic sensorineural deafness. Testing is offered to patients likely to receive aminoglycosides and also to individuals with hearing loss, particularly where maternal inheritance has been noted.

Also known as

mitochondrial deafness


Request a test

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Additional information

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Sending address

Great Ormond Street Hospital NE Thames Regional Genetics Service Laboratories
Great Ormond Street Hospital for Children
Barclay House
37 Queen Square
London
WC1N 3BH

Laboratory service

Genetics


Sample requirements

Blood sample in EDTA


Reference range

Not applicable


Turnaround time

10 days


Disease / group

m.1555A>G


Cost

Upon request


Call in advance?

Not required


Genetics

The Genetics Laboratories provide an extensive range of Cytogenetics and Molecular Genetics diagnostic testing services...

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