Autoimmune Profile


Description

Autoimmune Profile


Request a test

To request this test please send sample with a request providing patient ID (three identifiers), specimen information, assay required, relevant clinical details and sender information. Before sending sample please read details on requesting and labelling by clicking on the link. Please also refer to any additional information provided for this test. Download the referral form >


Additional information

Run at a titre of: 1:40; Detects the following antibodies: Smooth muscle (SM): often a non-specific finding. Occurs in type I autoimmune hepatitis (along with ANA). Also found in some patients with Hepatitis A and C infections. Liver kidney microsome (LKM) found in Type 2 autoimmune hepatitis . Also occurs in Hepatitis C. Mitochondrial (MITO) : found in primary biliary cirrohsis (a rare disease in children) Reticulin: false positives frequently found. Positive in coeliac disease with low specificity and sensitivity Gastric partietal cell (GPC): found in pernicious anaemia. This is very rare in children


Sending address

Immunology Department
Level 4, Camelia Botnar Laboratories
Great Ormond Street Hospital
Great Ormond Street
WC1N3JH

Laboratory service

Immunology


Sample requirements

1 ml serum


Reference range

Negative


Turnaround time

8 days


Disease / group

Several - suspected autoimmunity


Cost

Upon request


Call in advance?

Not required


Immunology

The Clinical Immunology Laboratory at GOSH provides a dedicated paediatric immunology service, supported by an expert scientific and clinical team.

© 2011 Great Ormond Street Hospital for Children NHS Trust