del(7q)/Monosomy 7 FISH


Description

A locus-specific dual-colour probe set for the detection of gains or losses of the chromosome 7 centromere and 7q31 regions. This probe set may also be used in other disease types/referral reasons for eluciation of rearrangements.

Also known as

D7S486/CEP7 FISH


Request a test

When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test. Download the referral form >


Additional information

FISH (fluorescence in-situ hybridisation) is a technique which used as both a stand-alone test and as an adjuct to G-band analysis. It uses uses fluorescently-labelled complementary sequesnces of DNA applied to material fixed on slides, this allows visulisation of specific sequences in both metaphase and interphase cells. Probes are designed for the analysis of specific rearrangments, or may be used for the enumeration of loci present in a cell. The information gained from FISH analyses may be useful for both diagnostic and prognostic purposes. May be performed as a reflex test on existing karyotyping cases.


Sending address

Paediatric Malignancy Unit Great Ormond Street Hospital for Sick Children Level 2, Camelia Botnar Laboratories Great Ormond Street London WC1N 3JH

Laboratory service

Paediatric Malignancy Unit


Sample requirements

Please refer to FISH (Tissue Fresh/frozen), FISH (FFPE) or FISH (Bone marrow/peripheral blood) as appropriate.


Reference range

Not applicable


Turnaround time

Urgent: 3 days (FISH only) As part of full karyotype anaysis; see 'Karyotype' turnaround times.


Disease / group

AML, MDS, acute myeloid leukaemia, myelodysplastic syndrome


Cost

Upon request


Call in advance?

Please call in advance to discuss requirements


Paediatric Malignancy Unit

The Paediatric Malignancy Unit is a unit providing a wide range of molecular genetic and cytogenetic diagnostic tests.

© 2011 Great Ormond Street Hospital for Children NHS Trust