ETV6-NTRK3 (Infantile fibrosarcoma)


Translocation Detection by Reverse transcriptase polymerase chain reaction (RT-PCR). All tests are designed to amplify PCR products less than 200bp. All tests are comlemented by amplification of a relevant housekeeping gene to test the quality of the RNA.

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When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test. Download the referral form >

Additional information

Occurs in infants and youn children. Genetically related to congenital mesoblastic nephroma and histologically identical to classical fibrosarcoma. Most cases exhibit a ETV6-NTRK3 fusion gene which can be detected by RT-PCR. This test is complementd by FISH using the ETV6 breakaprt probe.

Sending address

Paediatric Malignancy Unit Great Ormond Street Hospital for Sick Children Level 2, Camelia Botnar Laboratories Great Ormond Street London WC1N 3JH

Laboratory service

Paediatric Malignancy Unit

Sample requirements

Fresh, frozen or FFPE tissue. If sending FFPE rolled tissue sections please send the equivalent of 80 uM of tissue.

Reference range

Not applicable

Turnaround time

3-5 working days

Disease / group

Infantile fibrosarcoma


Upon request

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Paediatric Malignancy Unit

The Paediatric Malignancy Unit is a unit providing a wide range of molecular genetic and cytogenetic diagnostic tests.

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