KRAS mutation detection


Description

Bidirectional sequencing of exons 2 and 3


Request a test

When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test. Download the referral form >


Additional information

Juvenile myelomonocytic leukaemia (JMML) is an aggressive myeloproliferative disorder (MPD) characterized by the over-production of myeloid lineage cells. Children with neurofibromatosis type 1 (NF1) and Noonan syndrome are at increased risk of developing JMML.Somatic NRAS and KRAS mutations are found in 25% of JMML bone marrows, but are restricted to children who do not have NF1.


Sending address

Paediatric Malignancy Unit Great Ormond Street Hospital for Sick Children Level 2, Camelia Botnar Laboratories Great Ormond Street London WC1N 3JH

Laboratory service

Paediatric Malignancy Unit


Sample requirements

5 mls EDTA peripheral blood


Reference range

Not applicable


Turnaround time

20-30 working days


Disease / group

Juvenile Myelomonocytic Leukemia


Cost

Upon request


Call in advance?

Please call in advance to discuss requirements


Paediatric Malignancy Unit

The Paediatric Malignancy Unit is a unit providing a wide range of molecular genetic and cytogenetic diagnostic tests.

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