A locus specific dual-colour breakapart probe set for the detection of TCF3 rearrangements, but will not identify the partner gene involved. This probe set may also be used in other disease types/referral reasons for eluciation of rearrangements or locus enumeration.

Also known as


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When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test. Download the referral form >

Additional information

FISH (fluorescence in-situ hybridisation) is a technique which used as both a stand-alone test and as an adjuct to G-band analysis. It uses uses fluorescently-labelled complementary sequesnces of DNA applied to material fixed on slides, this allows visulisation of specific sequences in both metaphase and interphase cells. Probes are designed for the analysis of specific rearrangments, or may be used for the enumeration of loci present in a cell. The information gained from FISH analyses may be useful for both diagnostic and prognostic purposes. May be performed as a reflex test on existing karyotyping cases.

Sending address

Paediatric Malignancy Unit Great Ormond Street Hospital for Sick Children Level 2, Camelia Botnar Laboratories Great Ormond Street London WC1N 3JH

Laboratory service

Paediatric Malignancy Unit

Sample requirements

Please refer to FISH (Tissue Fresh/frozen), FISH (FFPE) or FISH (Bone marrow/peripheral blood) as appropriate.

Reference range

Not applicable

Turnaround time

Urgent: 3 days (FISH only) As part of full karyotype anaysis; see 'Karyotype' turnaround times.

Disease / group

ALL, acute lymphoblastic leukaemia


Upon request

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Please call in advance to discuss requirements

Paediatric Malignancy Unit

The Paediatric Malignancy Unit is a unit providing a wide range of molecular genetic and cytogenetic diagnostic tests.

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