PAX3-FKHR


Description

Translocation Detection by Reverse transcriptase polymerase chain reaction (RT-PCR). All tests are designed to amplify PCR products less than 200bp. All tests are comlemented by amplification of a relevant housekeeping gene to test the quality of the RNA.


Request a test

When requesting this test please use the referral form provided. Please also refer to any additional information provided for this test. Download the referral form >


Additional information

Alveolar rhabdomyosarocma is a primitive maligant round cell tumour which can occur at any age but primarily in younger children as well as adolescents and young adults. A PAX3-FKHR fusion gene is detected in approximately 70% of cases with a further 10% demonsttrating a variant PAX7-FKHR


Sending address

Paediatric Malignancy Unit Great Ormond Street Hospital for Sick Children Level 2, Camelia Botnar Laboratories Great Ormond Street London WC1N 3JH

Laboratory service

Specialist Integrated Haematology and Malignancy Diagnostic Service- Acquired Genomics


Sample requirements

Fresh, frozen or FFPE tissue. If sending FFPE rolled tissue sections please send the equivalent of 80 uM of tissue.


Reference range

Not applicable


Turnaround time

3-5 working days


Disease / group

Rhabdomyosarcoma


Cost

Upon request


Call in advance?

Please call in advance to discuss requirements


Specialist Integrated Haematology and Malignancy Diagnostic Service- Acquired Genomics (SIHMDS-AG)

Specialist Integrated Haematology and Malignancy Diagnostic Service- Acquired Genomics (SIHMDS-AG) is a laboratory providing a wide range of molecular genetic and cytogenetic diagnostic tests.

© 2011 Great Ormond Street Hospital for Children NHS Trust